I am currently an INSERM research fellow at the Institut de la Vision in Paris, specializing in the development of the visual system and the generation of genome-editing tools.
During my PhD at the University of Heidelberg in Germany (Centre for Organismal Studies), I identified the genetic cascade leading to the neuronal diversification of a cell type in the retina, the amacrine cells. I also studied the development of a population of commissural neurons during zebrafish brain formation and required to transmit information between the two cerebral hemispheres.
In 2014, I joined Dr. Del Bene’s laboratory (Institut Curie, Paris – France, then since 2019 Institut de la Vision, Paris – France) where I helped establish genome-editing tools for modeling human pathologies using zebrafish, which have 70% genetic homology with humans.
Additionnaly, since 2022 I have been developing and leading a sub-team on my research axis, whose aim is to identify the regulatory networks linked to the Redox pathway that control the balance between differentiation and homeostasis of retinal progenitor cells, both in zebrafish, and in a cultured model of human retinogenesis, retinal organoids. In the long term, this will enable us to optimize therapeutic cell replacement protocols for retinopathies and other neurodegenerative disorders involving oxidative stress.
Since 2023, I have been putting all this genetic, neurodevelopmental and translational expertise at the service of the Fondation Cotrel, with several of the projects I’ve supported using zebrafish as a model for studying scoliosis, and others exploring the link between visual function and scoliosis.