Dr Pascal Swider

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Dr Pascal Swider

Institut de mécanique des fluides, Toulouse, France

Biomechanical, Laureate 2011

Adolescent idiopathic scoliosis is a multifactorial disease affecting up to 3% of the adolescent population during the growth spurt, with a prevalence in females. We were the first to propose the exploration of disc response in the evolution of scoliosis using MRI, and our current research aims to correlate growth-related, metabolic and biomechanical factors in clinical cohorts.
As part of an innovative methodology, we hypothesize that the interdisciplinary approach combining image-based clinical data (X-ray and diffusion MRI), metabolic factors and energy-based biomechanical models gives access to a) plausible mechanobiological scenarios to describe the evolution of AIS, and b) the proposal of new markers.
The clinical relevance of our research concerns the divergence between stable and progressive scoliosis and surgical planning.
Our research addresses societal challenges related to understanding and promoting health and well-being. The results improve patient care and comfort, and help reduce healthcare costs.

Publications

Violas P, Estivalèzes E, Pédrono A, de Gauzy JS, Sévely A, Swider P. A method to investigate intervertebral disc morphology from MRI in early idiopathic scoliosis: a preliminary evaluation in a group of 14 patients. Magn Reson Imaging. 2005 Apr;23(3):475-9. doi: 10.1016/j.mri.2004.12.004.
Violas P, Estivalezes E, Briot J, Sales de Gauzy J, Swider P. Objective quantification of intervertebral disc volume properties using MRI in idiopathic scoliosis surgery. Magn Reson Imaging. 2007 Apr;25(3):386-91. doi: 10.1016/j.mri.2006.09.007.
Violas P, Estivalezes E, Briot J, Sales de Gauzy J, Swider P. Quantification of intervertebral disc volume properties below spine fusion, using magnetic resonance imaging, in adolescent idiopathic scoliosis surgery. Spine (Phila Pa 1976). 2007 Jul 1;32(15):E405-12. doi: 10.1097/BRS.0b013e318074d69f.
Accadbled F, Laffosse JM, Ambard D, Gomez-Brouchet A, de Gauzy JS, Swider P. Influence of location, fluid flow direction, and tissue maturity on the macroscopic permeability of vertebral end plates. Spine (Phila Pa 1976). 2008 Mar 15;33(6):612-9. doi: 10.1097/BRS.0b013e318166e0d7.
Swider P, Pédrono A, Ambard D, Accadbled F, Sales de Gauzy J. Substructuring and poroelastic modelling of the intervertebral disc. J Biomech. 2010, 7;43(7):1287-91. doi: 10.1016/j.jbiomech.2010.01.006.
Abelin-Genevois K, Estivalezes E, Briot J, Sévely A, Sales de Gauzy J, Swider P. Spino-pelvic alignment influences disc hydration properties after AIS surgery: a prospective MRI-based study. Eur Spine J. 2015 Jun;24(6):1183-90. doi: 10.1007/s00586-015-3875-4.
Bolzinger M, Estivalèzes E, Gallini A, Polirsztok E, Abelin-Genevois K, Baunin C, Sales de Gauzy J, Swider P. MRI evaluation of the hydration status of non-pathological lumbar intervertebral discs in a pediatric population. Orthop Traumatol Surg Res. 2020 Nov;106(7):1281-1285. doi: 10.1016/j.otsr.2019.11.034.
Brun-Cottan B, Assemat P, Doyeux V, Accadbled F, Sales de Gauzy J, Compagnon R, Swider P. An energy approach describes spine equilibrium in adolescent idiopathic scoliosis. Biomech Model Mechanobiol. 2021 Feb;20(1):359-370. doi: 10.1007/s10237-020-01390-9.
Compagnon R, Brun-Cottan B, Assemat P, Vial J, Sales de Gauzy J, Swider P. Diffusion properties of asymptomatic lumbar intervertebral discs in a pediatric cohort: a preliminary study of apparent diffusion coefficient. Eur Spine J. 2022 Nov;31(11):2943-2949. doi: 10.1007/s00586-022-07342-4.

Financing a research project

Training in screening

Scolimpiades: screening near you

Does your child have scoliosis?

Yves Cotrel Foundation

Mrs Nora Muller-Conte
Delegate of the Foundation
Fondation Yves Cotrel
Institut de France
23, Quai de Conti – 75006 Paris France

Institute of France

23, Quai de Conti, 75006 Paris France

Dr Pascal Swider

Publications

Financing a research project

Training in screening

Scolimpiades: screening near you

Does your child have scoliosis?

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