Dr Guillaume Pezeron

Museum d’Histoire Naturelle, Paris, France
Métabolique, Lauréat 2022

Guillaume Pezeron is a lecturer in the Molecular Physiology of Adaptation Laboratory at the Museum National d’Histoire Naturelle.

He is co-leader of the “Development, evolution and functions of neurosecretory systems” research team. His projects aim to determine the functions of a family of peptic hormones called Urotensin 2, using the zebrafish as a study model. He recently described for the first time that the absence of two hormones from this family (Urp1 and Urp2) leads to severe spinal deformity, presumably because they are necessary for regulating trunk muscle tone. With the support of the Fondation Cotrel, he is working to better understand the role of these hormones in maintaining the integrity of the spine.

Publications

Djebar M., Anselme I., Pézeron G., Bardet P.L., Cantaut‐Belarif Y., Eschstruth A., López‐ Santos D., Le Ribeuz H., Jenett A., Khoury H., Veziers J., Parmentier C., Hirschler A., Carapito C., Bachmann‐Gagescu R., Schneider‐Maunoury S., and Vesque C. (2024) Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction. eLife, 13.

Gaillard A.L., Mohamad T., Quan F.B., de Cian A., Mosimann C., Tostivint H., and Pézeron G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Devel‐ opmental biology, 496:36–51. As corresponding author

Tostivint H., Alejevski F., Leemans M., Gaillard A.L., Le Mével S., Herrel A., Fini J.B., and Pézeron G. (2022) Des neuropeptides impliqués dans la morphogenèse de l’axe vertébral : Les leçons du poisson et du crapaud. Medecine sciences, 38:27–29.

Alejevski F., Leemans M., Gaillard A.L., Leistenschneider D., de Flori C., Bougerol M., Le Mével S., Herrel A., Fini J.B., Pézeron G., and Tostivint H. (2021) Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod. Open biology, 11:210065.

Quan F.B., Gaillard A.L., Alejevski F., Pézeron G., and Tostivint H. (2021) Urotensin II‐related peptide (Urp) is expressed in motoneurons in zebrafish, but is dispensable for locomotion in larva. Peptides, 146:170675.

Cantaut‐Belarif Y., Orts Del’Immagine A., Penru M., Pézeron G., Wyart C., and Bardet P.L. (2020) Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid‐contacting neurons during development. eLife, 9.