Christine Vesque works in Sylvie Schneider-Maunoury’s team at the Institut de Biologie Paris-Seine (IBPS) within the Dev2A unit.
The team is interested in the mechanisms of vertebrate nervous system morphogenesis. It focuses on the function of primary cilia during nervous system development, juvenile growth and homeostasis.
The generation of zebrafish mutants for genes encoding ciliary proteins has revealed severe and penetrating scoliotic phenotypes at juvenile stages, mimicking idiopathic scoliosis (IS) in humans. Late axis curvature in zebrafish is associated with neuroinflammation and astrogliosis. One of our projects is to understand the link between primary cilia dysfunction and neuroinflammation/astrogliosis, and to study the function of primary cilia during intervertebral disc formation.
This project will shed light on the mechanisms of axis curvature, some of which may be conserved in humans.
- mullerconte@fondationcotrel.org
- +33(0)1 44 41 44 47
