Professeur Jeremy Fairbank

Nuffield Orthopaedic Center, Oxford, Royaume-Uni
Biomécanique, Lauréat 2000 et 2007

Jeremy Fairbank a été formé à la chirurgie orthopédique de la colonne vertébrale à l’université de Cambridge, à l’hôpital Saint Thomas de Londres et à Oswestry. Il est professeur émérite de chirurgie de la colonne vertébrale à l’université d’Oxford.

Il travaille depuis plus de 10 ans sur l’annotation automatisée de l’imagerie de la colonne vertébrale (DEXA, radiographies, IRM et tomodensitogrammes). Il applique désormais ces techniques à l’extraction d’informations à partir de grands ensembles de données au Royaume-Uni, tels que ALSPAC, une cohorte établie pour des naissances en 1991/2 et dont les participants ont aujourd’hui plus de 35 ans. Ces personnes ont passé des scanners DEXA entre leurs 9 ans et 24 ans, ce qui permet de suivre l’évolution de leur scoliose : 5,9 % des quelque 10000 participants présentent une scoliose.

D’autres grands ensembles de données sont UK Biobank (0,5 million de participants) et TwinsUK (~8k participants avec des scanners DEXA). Tous ces ensembles de données contiennent des informations génomiques. Jeremy Fairbank et ses équipes combinent les informations provenant de ces ressources pour développer de nouvelles méthodes de dépistage et de diagnostic de la scoliose le plus tôt possible, avant qu’elle n’ait une chance d’évoluer.

Jeremy Fairbank a été président de la British Scoliosis Society et de l’ISSLS, la Société internationale pour l’étude de la colonne lombaire. Il a été conseiller de recherche invité à l’Institut Calot de Berck plusieurs années au cours des années 90

Publications

  1. Theologis T, Jefferson R, Simpson A, Turner-Smith A, Fairbank J. Quantifying the cosmetic defect of adolescent idiopathic scoliosis. Spine 1993;18:909-912.
  2. Bartels E, Fairbank J, Winlove C, Urban J. Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine 1998;23:1-8.
  3. Urban M, Fairbank J, Bibby S, Urban J. Intervertebral disc composition in neuromuscular scoliosis: changes in cell density and glycosaminoglycan concentration at the curve apex. Spine 2001;26:610-617.
  4. Urban M, Fairbank J, Etherington P, Loh L, Winlove C, Urban J. Electrochemical measurement of transport into scoliotic intervertebral discs in vivo using nitrous oxide as a tracer. Spine 2001;26:984-990
  5. Bibby S, Fairbank J, Urban M, Urban J. Cell viability in scoliotic discs in relation to disc deformity and nutrient levels. Spine 2002;27:2220-2226.
  6. Yu J, Fairbank J, Urban J. The association between the accumulation of elastic fibres and local cell proliferation in annulus of intervertebral disc. Int. J. Exp. Path 2003;84:A81.
  7. Fairbank J. Historical perspective: William Adams, the forward bending test, and the spine of Gideon Algernon Mantell. Spine 2004;29(17):1953-1955.
  8. Yu J, Fairbank J, Roberts S, Urban J. The Elastic Fiber Network of the Anulus Fibrosus of the Normal and Scoliotic Human Intervertebral Disc. Spine 2005;30(16):1815-1820.
  9. Yu J, Tirlapur U, Fairbank J, et al. Microfibrils, elastin fibres and collagen fibres in the human intervertebral disc and bovine tail disc. J Anat 2007;210:460–471.
  10. Meir, J. Fairbank, D. Jones, D. McNally and J. Urban. High pressures and asymmetrical stresses in the scoliotic disc in the absence of muscle loading. Scoliosis 2007 Vol. 2 Pages 4.
  11. Meir, D. McNally, J. Fairbank, D. Jones and J. Urban. The internal pressure and stress environment of the scoliotic intervertebral disc – a review. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 2008 Vol. 222 Issue 2 Pages 209-219. DOI: 10.1243/09544119JEIM303
  12. Berryman F, Pynsent P, Fairbank J, Disney S. A new system for measuring three-dimensional back shape in scoliosis. European Spine Journal 2008;17(5):663-672.
  13. Williams M, Heine P, Williamson E, Toye F, Dritsaki M, Petrou S, et al. Active Treatment for Idiopathic Adolescent Scoliosis (ACTIvATeS): a feasibility study. Health Technol Assess. 2015;19(55):1-242.
  14. Belavy D, Adams M, Brisby H, Cagnie B, Danneels L, Fairbank J, et al. Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth? Eur Spine J. 2016;25(1):144–54.
  15. Clark, E., J. Tobias and J. Fairbank. « The Impact of Small Spinal Curves in Adolescents Who Have Not Presented to Secondary Care: A Population-Based Cohort Study. » Spine 2016;41(10): E611–E617.
  16. Jamaludin, A., M. Lootus, T. Kadir, A. Zisserman, J. Urban, M. Battié, J. Fairbank, I. McCall and Genodisc Consortium (2017). « Automation of reading of radiological features from magnetic resonance images (MRIs) of the lumbar spine without human intervention is comparable with an expert radiologist. » European Spine Journal. doi: 10.1007/s00586-017-4956-3
  17. Nnadi, C., C. Thakar, J. Wilson-MacDonald, P. Milner, A. Rao, D. Mayers, J. Fairbank and T. Subramanian (2018). « An NIHR-approved two-year observational study on magnetically controlled growth rods in the treatment of early onset scoliosis. » The Bone & Joint Journal 100-B(4).
  18. Tobias, J., J. Fairbank, I. Harding, H. Taylor and E. Clark (2018). « Association between physical activity and scoliosis: A prospective cohort study. » International Journal of Epidemiology. 48(4); 1152-1160
  19. Thakar, C., D. Kieser, M. Mardare, S. Haleem, J. Fairbank and C. Nnadi (2018). « Systematic review of the complications associated with magnetically controlled growing rods for the treatment of early onset scoliosis. » European Spine Journal 27(9): 2062–2071.
  20. Tobias JH, Fairbank J, Harding I,Taylor HJ,Clark EM (2018). Association between physical activity and scoliosis: A prospective cohort study. International Journal of Epidemiology doi: 10.1093/ije/dyy268
  21. Tobias J, Fairbank J, Harding I, Taylor H, Clark E. Association between physical activity and scoliosis: A prospective cohort study. International Journal of Epidemiology. 2019;48(4):1152–60.
  22. Jamaludin A, Fairbank J, Harding I, Kadir T, Peters T, Zisserman A, et al. Identifying scoliosis in population-based cohorts: Automation of a validated method based on total body dual energy X-ray absorptiometry scans. Calcif Tissue Int. 2020;106(4):378-85.
  23. Bourigault, A. Jamaludin, E. Clark, J. Fairbank, T. Kadir, A. Zisserman. 3D Shape Analysis of Scoliosis. In book: Shape in Medical Imaging (pp.271-286) October 2023. DOI:10.1007/978-3-031-46914-5_22
  24. Jamaludin, J. Fairbank, I. Harding, T. Kadir, A. Zisserman and E. Clark. Automated measurement of size of spinal curve in population-based cohorts: validation of a method based on total body dual energy X-ray absorptiometry scans. BONE 2023 Vol. 172 Pages 116775. Accession Number: 37080371 PMCID: PMID: 37080371 DOI: doi: 10.1016/j.bone.2023.116775